Recent Publications

Wanjie Wu, Yingzhu He, Yujun Chen, Yiming Fu, Sicong He, Kai Liu, Jianan Y. Qu (2024). In Vivo Imaging in Mouse Spinal Cord Reveals that Microglia Prevent Degeneration of Injured Axons. Nature Communications, (2024).

Jiahao Chen, Honggao WANG, Shuting Wu, Ao Zhang, Zhongkai Qiu, Peng HUANG, Jianan Y.Qu, Jin Xu (2024). col1a2+ fibroblasts/muscle progenitors finetune xanthophore countershading by differentially expressing csf1a/1b in embryonic zebrafish. Science Advances, (2024).

Zhujuan Huang, Yongtai Xu, Zhongkai Qiu, Yunyun Jiang, Jiaye Wu, Qing Liu, Sicong He, Jianan Y. Qu, Jiahao Chen, Jin Xu (2024). Caudal hematopoietic tissue supports definitive erythrocytes via epoa and is dispensable for definitive neutrophils. Journal of Genetics and Genomics, (2024).

Yingzhu He, Youshan Heng, Zhongya Qin, Xiuqing Wei, Zhenguo Wu, Jianan Qu (2023). Intravital microscopy of satellite cell dynamics and their interaction with myeloid cells during skeletal muscle regeneration. Science Advances, (2023).

Min Liu, Chunjian Wu, Rui Wang, Jiaming Qiu, Zhentao SHE, Jianan Qu, Jiang Xia (2023). Modulating Liquid–Liquid Phase Separation of Nck Adaptor Protein against Enteropathogenic Escherichia coli Infection. ACS Cent. Sci., 9,12,2358-2368 (2023).

Ao Zhang, Jingao Lu, Shachuan Feng, Huapeng Yu, Tao Yu, Shizheng Zhao, Kemin Chen, Zhibin Huang, Jin Xu, Jianan Y.Qu, Zilong Wen (2023). Fli1 acts in parallel with Pu.1 to control macrophage and neutrophil fate in zebrafish. Journal of Genetics and Genomics, (2023).

Wanjie Wu, Sicong He, Yujun Chen, Congping Chen, Yiming Fu, Kai Liu, Jianan Y. Qu (2023). Minimally invasive microglial and neuronal imaging in mouse spinal cord dorsal horn (Invited paper). IEEE Journal of Selected Topics in Quantum Electronics, (2023).

Xiao Li, Ling He, Xiaohan Hu, Fengwen Huang, Xue Wang, Mengying Chen, Ezra Ginn Yoon, Stephen Temitayo Bello, Tao Chen, Xi Chen, Peng Tang, Congping Chen, Jianan Qu, Jufang He (2023). Interhemispheric cortical long-term potentiation in the auditory cortex requires heterosynaptic activation of entorhinal projection. iScience, 26, 4,(2023).

Zhongya Qin, Zhentao SHE, Congping Chen, Wanjie Wu, Jackie K.Y. Lau, Nancy Y. Ip, Jianan Y. Qu (2022). Deep tissue multi-photon imaging using adaptive optics with direct focus sensing and shaping. Nature Biotechnology, (2022).

Yue Wang, Min Liu, Qixin Wei, Wanjie Wu, Yanping He, Jiayang Gao, Renjie Zhou, Liwen Jiang, Jianan Qu, Jiang Xia (2022). ‘Phase‐Separated Multienzyme Compartmentalization for Terpene Biosynthesis in a Prokaryote'. Angewandte Chemie International Edition, (2022).

Wanjie Wu, Sicong He, Junqiang Wu, Congping Chen, Xuesong Li, Kai Liu, Jianan Y. Qu (2022). ‘Long-term in vivo imaging of mouse spinal cord through an optically cleared intervertebral window'. Nature Communications, V. 13, 1959 (2022).

Wanjie Wu, Xuesong Li, Jianan Y. Qu, Sicong He (2021). In vivo Imaging of Biological Tissues with Combined Two-Photon Fluorescence and Stimulated Raman Scattering Microscopy. J. Vis. Exp. (JoVE), (178), e63411 (2021).

Congping Chen, Zhentao SHE, Peng Tang, Zhongya Qin, Jufang He, Jianan Y.Qu (2021). Study of neurovascular coupling by using mesoscopic and microscopic imaging. iScience, V. 24, 10, 22 October 2021, 103176.

Lidan Zeng, Xuesong Li, Christopher B. Preusch, Gary J. He, Ningyi Xu, Tom H. Cheung, Jianan. Qu, Ho Yi Mak (2021). Nuclear receptors NHR-49 and NHR-79 promote peroxisome proliferation to compensate for aldehyde dehydrogenase deficiency in C. elegans. PLoS Genetics, 17(7): e1009635. (2021).

Congping Chen, Zhongya Qin, Sicong He, Shaojun Liu, Shun-Fat Lau, Wanjie Wu, Dan Zhu, Nancy Y. Ip, Jianan Y. Qu (2021). High-resolution two-photon transcranial imaging of brain using direct wavefront sensing. Photonics Research, Vol. 9, Issue 6, pp. 1144-1156 (2021).

Ye Wang, Wing-Yu Fu, Kit Cheung, Kwok-Wang Hung, Congping Chen, Hongyan Geng, Wing-Ho Yung, Jianan Y. Qu, Amy K. Y. Fu, Nancy Y. Ip (2020). Astrocyte-secreted IL-33 mediates homeostatic synaptic plasticity in the adult hippocampus. Proceedings of the National Academy of Sciences of the United States of America, V.118, (2021).

Qixin Wei, Sicong He, Jianan Qu, Jiang Xia (2020). Synthetic Multienzyme Complexes Assembled on Virus-like Particles for Cascade Biosynthesis In Cellulo. Bioconjugate Chemistry, 2020, 31, 10, 2413–2420.

Zhongya Qin, Congping Chen, Sicong He, Ye Wang, Kam Fai Tam, Nancy Y. Ip, Jianan Y. Qu (2020). Adaptive optics two-photon endomicroscopy enables deep brain imaging at synaptic resolution over large volumes. Science Advances, 30 Sep 2020: Vol. 6, no. 40, eabc6521.

Sicong He, Jin Xu, Jianan Qu, Zilong Wen (2020). Lightening the Way of Hematopoiesis: Infrared Laser-Mediated Lineage Tracing With High Spatial-Temporal Resolution. Experimental Hematology, V.85, P.3-7 (2020).

Zhongya Qin, Sicong He, Chao Yang, Jasmine Sum-Yee Yung, Congping Chen, Christopher Kai-Shun Leung, Kai Liu, Jianan Y. Qu (2020). Adaptive optics two-photon microscopy enables near-diffraction-limited and functional retinal imaging in vivo. Nature: Light Science & Applications, (2020)9:79.

Miao Liu, Sicong He, Lixin Cheng, Jianan Qu, Jiang Xia (2020). Phase-Separated Multienzyme Biosynthesis. Biomacromolecules, V.21, P.2391-2399 (2020).

Shun-Fat Lau, Congping Chen, Wing-Yu Fu, Jianan Y. Qu, Tom H. Cheung, Amy K.Y. Fu, Nancy Y. Ip (2020). IL-33-PU.1 Transcriptome Reprogramming Drives Functional State Transition and Clearance Activity of Microglia in Alzheimers Disease. Cell Reports, V.31, 107530 (2020).

Sicong He, Ye Tian, Shachuan Feng, Yi Wu, Xinwei Shen, Kani Chen, Yingzhu He, Qiqi Sun, Xuesong Li, Jin Xu, Zilong Wen, Jianan Y Qu (2020). In vivo single-cell lineage tracing in zebrafish using high-resolution infrared laser-mediated gene induction microscopy. eLife, 2020;9:e52024.

Sicong He, Xiuqing Wei, Zhongya Qin, Congping Chen, Zhenguo Wu, Jianan Y Qu (2019). In vivo study of metabolic dynamics and heterogeneity in brown and beige fat by label-free multiphoton redox and fluorescence lifetime microscopy. Journal of Biophotonics, 2019;e201960057.

Wei Kang, Tian Ma, Min Liu, Jiale Qu, Zhenjun Liu, Huawei Zhang, Bin Shi, Shuai Fu, Juncai Ma, Louis Tung Faat Lai, Sicong He, Jianan Qu, Shannon Wing-Ngor Au, Byung-Ho Kang, Wilson Chun Yu Lau, Zixin Deng, Jiang Xia, Tiangang Liu (2019). Modular enzyme assembly for enhanced cascade biocatalysis and metabolic flux. Nature Communications, (2019) 10:4248.

Zhe Cao, Yan Hao, Chun Wing Fung, Yiu Yiu Lee, Pengfei Wang, Xuesong Li, Kang Xie, Wen Jiun Lam, Yifei Qiu, Ben Zhong Tang, Guanghou Shui, Pingsheng Liu, Jianan Qu, Byung-Ho Kang, Ho Yi Mak (2019). Dietary fatty acids promote lipid droplet diversity through seipin enrichment in an ER subdomain. Nature Communications, (2019) 10:2902.

Xuesong Li, Yan Li, Meijuan Jiang, Wanjie Wu, Sicong He, Congping Chen, Zhongya Qin, Yifei Qiu, Ben Zhong Tang, Ho Yi Mak, Jianan Y. Qu (2018). Quantitative Imaging of Lipid Synthesis and Lipolysis Dynamics in Caenorhabditis elegans by Stimulated Raman Scattering Microscopy. Analytical Chemistry, Vol.91 (3), 2279-2287 (2019).

Congping Chen, Zhuoyi Liang, Biao Zhou, Xuesong Li, Caleb Lui, Nancy Y. Ip, Jianan Y. Qu (2018). In Vivo Near-infrared two-photon imaging of amyloid plaques in deep brain of Alzheimers disease mouse model. ACS Chemical Neuroscience, Vol. 9, No.12, 3128-3136 (2018).

Guangle Niu, Ruoyao Zhang, John P. C. Kwong, Jacky W. Y. Lam, Congping Chen, Jianguo Wang, Yuncong Chen, Xing Feng, Ryan T. K. Kwok, Herman H.-Y. Sung, Ian D. Williams, Mark R. J. Elsegood, Jianan Qu, Chao Ma, Kam Sing Wong, Xiaoqiang Yu, Ben Zhong Tang (2018). Specific Two-Photon Imaging of Live Cellular and Deep-Tissue Lipid Droplets by Lipophilic AIEgens at Ultralow Concentration. Chemistry of Materials, Vol. 30 (14), 4778-4787 (2018).

Sicong He, Yitai An, Xuesong Li, Xiuqing Wei, Qiqi Sun, Zhenguo Wu, Jianan Y. Qu (2018). In vivo metabolic imaging and monitoring of brown and beige fat. Journal of Biophotonics, 11(8), e201800019.(2018).

Zhongya Qin, Qiqi Sun, Yue Lin, Sicong He, Xuesong Li, Congping Chen, Wanjie Wu, Yi Luo, Jianan Y. Qu (2018). New fluorescent compounds produced by femtosecond laser surgery in biological tissues: the mechanisms. Biomedical Optics Express, Vol. 9, No. 7, 3374-90 (2018).

Sicong He, Jiahao Chen, Yunyun Jiang, Yi Wu, Lu Zhu, Wan Jin, Changlong Zhao, Tao Yu, Tienan Wang, Shuting Wu, Xi Lin, Jianan Y Qu, Zilong Wen, Wenqing Zhang, Jin Xu (2018). Adult zebrafish Langerhans cells arise from hematopoietic stem/progenitor cells. eLife, Vol. 7 (2018).

Qiqi Sun, Zhongya Qin, Wanjie Wu, Yue Lin, Congping Chen, Sicong He, Xuesong Li, Zhenguo Wu, Yi Luo, Jianan Y. Qu (2018). In vivo imaging-guided microsurgery based on femtosecond laser produced new fluorescent compounds in biological tissues. Biomedical Optics Express, Vol. 9, No. 2, 581-90 (2018).

Xuesong Li, Meijuan Jiang, Jacky W. Y. Lam, Ben Zhong Tang, Jianan Y. Qu (2017). Mitochondrial Imaging with Combined Fluorescence and Stimulated Raman Scattering Microscopy Using a Probe of the Aggregation-Induced Emission Characteristic. Journal of the American Chemical Society, Vol. 139, No.47, 17022-17030 (2017).

Meijuan Jiang, Ryan T. K. Kwok, Xuesong Li, Chen Gui, Jacky W. Y. Lam, Jianan Qu, Ben Zhong Tang (2017). A simple mitochondrial targeting AIEgen for image-guided two-photon excited photodynamic therapy. Journal of Materials Chemistry B, Vol. 6, No.17, 2557-2565 (2018).

Alexander Nicol, Ryan T. K. Kwok, Congping Chen, Weijun Zhao, Ming Chen, Jianan Qu, Ben Zhong Tang (2017). Ultrafast Delivery of Aggregation-Induced Emission Nanoparticles and Pure Organic Phosphorescent Nanocrystals by Saponin Encapsulation. Journal of the American Chemical Society, V.139, 14792-14799 (2017).

Ye Tian, Jin Xu, Shachuan Feng, Sicong He, Shizheng Zhao, Lu Zhu, Wan Jin, Yimei Dai, Lingfei Luo, Jianan Y. Qu, Zilong Wen (2017). The first wave of T lymphopoiesis in zebrafish arises from aorta endothelium independent of hematopoietic stem cells. Journal of Experimental Medicine, Vol. 214, No.11, 3347-3360 (2017).

Sicong He, Wenqian Xue, Zhigang Duan, Qiqi Sun, Xuesong Li, Huiyan Gan, Jiandong Huang, Jianan Y. Qu (2017). Multimodal nonlinear optical microscopy reveals critical role of kinesin-1 in cartilage development. Biomedical Optics Express, Vol. 8, 1771-1782 (2017).